Synthesis of certain 1,3,4-oxadiazole derivatives of expected anti-inflammatory activity

ABSTRACT

The synthesis of certain diclofenac acid hydrazones 2a-k is described. The delta 2-1,3,4-oxadiazoline-5-thione 4 is prepared by reacting diclofenac acid hydrazide 1 with carbon disulfide in ethanolic potassium hydroxide. Some thio ethers 5a-f and Mannich bases 6a-f are prepared from the 1,3,4-oxadiazole derivative 4 and tested for their analgetic antipyretic and antiinflammatory activities. The given structures are confirmed by microanalyses and spectral data