Study on the effect of lsouramil on some pharmacological responses with special references to its thermoregulatory effects in rats

ABSTRACT

Isouramil [U] is an active aglycone of the glycoside convicine isolated from broad beans [Vicia Faba] with the capacity to autoxidize and generates hydrogen peroxide. The effect of successive reported doses [1.2 mg/100 g body weight] equivalent to 1/10 LD[50] ,of lsouramil in rats for two weeks on body temperature, hematology, some constituents of urine and blood glutathione were studied in male Sprague Dawely rats. There was a marked decrease in skin and tail temperatures but little effect on rectal temperature. Erythrocy1es decreased [P<0.05] after the second week of injection and haematocrite value increased [P<0.01] after both first and second weeks. Creatinine and haemoglobin levels in urine were significantly increased [p<0.05], while uric acid was not affected. Blood glutathione showed a significant [p<0.01] decrease after 2 hours of injection and still depleted all over the period of experiment