Synthesis of certain benzimidazole derivatives structurally related to antituberculous agents

ABSTRACT

Incorporation of an acid hydrazide, N2 substituted acid hydrazide or N4 substituted sulphonamide residues into a benzamidazole residue in a way fulfilling the required pattern for antituberculous activity in most antituberculous agents, with special reference to the highly potent isonicotinic acid hydrazide, has been achieved. This was verified via a 4-aminobenzoic acid or 4-aminobenzenesulphonamide link, which might create a type of competition between 4-aminobenzoic acid as a bacterial metabolite and the group of compounds