Study the effect of extremely low frequency electromagnetic fields on some blood serum's lipoproteins, liver enzymes and P448/P450 cytochrome enzyme system in NMRI female mice

ABSTRACT

Arterial diseases are the first causes of death in the developed countries. It seems necessary to investigate the role of enzymes, lipids, proteins and para-oxidation lipids in these diseases. The tribulation of fats is one of the most risk factors which results in atherosclerosis of coronary arteries. In this study, the short time effects of Extremely Low Frequency Electromagnetic Fields with the frequency of 50Hz, on the amount of some blood lipo-proteins, liver enzymes, P448 and P450 cytochrome enzyme system are investigated in the NMRI female mice. The results indicate that the blood serum's levels of lipoproteins decrease significantly, in comparison with control and sham groups [P<0.05]. Experimental groups of 3 and 5 showed significant increase of HDL compare with control and sham groups [P<0.001]. While levels of Aspartate aminotransferase [AST] increased in liver, Alanin aminotransferase [ALT] enzyme levels did not show any significant changes in experimental groups [P<0.01]. In addition, Ames test shows similarity in control and experimental liver extract in the reveres colonies, so the electromagnetic field with intensity of 0.06 militesla [P<0.01], does not disturb the P448/P450 enzyme system