Hypoxia: a review

ABSTRACT

Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption. Growing evidence from experimental and clinical studies points to the fundamental and pathophysiologic role of hypoxia in cancer, ischemic tolerance, and stroke. Hypoxia-induced changes in ion homeostasis, erythropoiesis, angiogenesis, proliferation and differentiation. This review outlines hypoxia effect at molecular level and describes briefly hypoxia role in the physiological and pathological conditions