Comparative study of postprandial hypertriglyceridemia in diabetic patients with occurrence of microalbuminuria

ABSTRACT

It has been demonstrated that Type 2 Diabetes Mellitus [T2DM] patients, with the presence of microalbuminuria [MA] had higher postprandial triglyceride than those without MA. The present study further investigates this potential association and to elaborate the degree of dependence of T2DM with MA condition on onset of high postprandial [PP] triglyceridemia in our setting. A total of 32 patients with T2DM were included in the study during February 2007 and December 2008 and were divided into two groups according to the presence [n = 15, MA+ve] or absence of MA [n=l 7, MA-ve]. Blood was drawn in the fasting state and at 2 and 6 h after the standard mixed breakfast test meal for biochemical analysts. Plasma ApoA, triglycerides, glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, creatinine and Glycosylated hemoglobin Ale [HbAlc] levels were determined using standard methods. 24 hr albumin and urinary micro albumin showed highly significant difference [P<0.001] in values in MA-ve and MA+ve groups, whereas glycosylated HbAlc and duration of T2DM doesn't exhibit any significant difference. Biochemical constituents such as glucose, total cholesterol and HDL-cholesterol exhibited mild [P<0.05] to moderate [P<0.01] significance when compared within the groups of MA-ve and MA +ve patients in fasting and postprandial conditions. Comparatively highest level of constantly significant difference in values was noted only in triglycerides when MA +ve were compared with MA-ve, which remains high not only at 2 hrs. Postprandial [P<0.001] but also after 6 hrs. Under same conditions [P<0.001]. The data strongly support the theory and observations that in patients with T2DM and co-existence of MA, hypertriglyceridemia prevails, which further complicates the already co-morbid hyperlipidemic state in these patients