Diagnostic utility of Amino-terminal pro-B type natriuretic peptide [NT pro BNP] in adult patients with chronic kidney diseases

ABSTRACT

In recent studies, suggestions were made that the diagnostic utility of Amino-terminal pro-B type natriuretic peptide [NT-proBNP] a known biomarkers of myocardial dysfunction, be extended to chronic kidney disease [CKD] patients that are devoid of any cardiovascular abnormalities or disease, however may develop same in future. The goal of present study was to further evaluate the relationship between CKD and NT-proBNP concentration in patients with varying levels of renal dysfunction including End Stage Renal Disease [ESRD]. Stable adult patients of both gender [n = 76] with CKD were included in the study during January 2007 to September 2008, who had been on hemodialysis [HD]. The patients were divided into two groups depending on Left ventricular ejection fraction [EF]<50%. Other parameters such as mean arterial pressure [MAP], NT proBNP and biochemical parameters were measured using standard procedures. The result strongly presents a correlation between of NT-proBNP levels in CKD patients, who were without a definite onset of LVD. Furthermore, NT pro-BNP significantly correlated with an elevated protein to creatinine ratio and blood urea nitrogen [P < 0.01] suggesting that onset and presence of CKD influenced the concentration of natriuretic peptides. The present study regarding assessment of NT proBNP in CKD patients, provide evidence that renal dysfunction and natriuretic peptides, especially NT-proBNP are correlated with each other. In addition, further prospective studies are underway to validate and better define this relationship