[Study of high glucose-induced toxicity and reactive oxygen species production and the protective effect of saffron extract in PC12 cells]

ABSTRACT

Background and Objective: diabetic neuropathy is one of the most frequent complications of diabetes. Despite some studies, the exact mechanism of glucose neurotoxicity has not been fully elucidated. Increased reactive oxygen species [ROS] has been proposed as a possible mechanism. Crocus sativus L. [saffron] has been known as a source of antioxidants. Therefore, neuroprotective effect of saffron extract was studied in glucose-induced neurotoxicity, using PC12 cells as a suitable in vitro model of diabetic neuropathy