Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (4): 1393-1397
in English
| IMEMR
| ID: emr-198439
ABSTRACT
2-[3-hydroxy-1-adamantyl]-2-oxoacetic acid [IV], a key intermediate of saxagliptin for type 2 diabetes mellitus [T2DM], was prepared from 1-adamantanecarboxylic acid[I] via oxidation by potassium permanganate[KMnO4] to afford 3-hydroxy-1-adamantanecarboxylic acid [II], which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane [III] followed by oxidation. Some key steps were optimized and the overall yield was about 51%
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2018
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