Detection of Y chromosome microdeletions and hormonal profile analysis of infertile men undergoing assisted reproductive technologies

ABSTRACT

Background: Y chromosome deletions [YCDs] in azoospermia factor [AZF] region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. Assisted reproductive tech- nologies [ART] by intracytoplasmic sperm injection [ICSI] and testicular sperm extraction [TESE] are commonly required for infertility management of patients carrying YCDs. The aim of this study was to estimate the frequency of YCDs, to find the most frequent variant in infertile men candidate for ART and to compare YCD distribution with a control fertile group. The semen parameters, hormonal profiles and ART outcomes of the infertile group were studied