Molecular detection of human herpes viruses 1, 2, 3 and 6 in the cerebrospinal fluid of patients with central nervous system infections

ABSTRACT

Background: Infections of central nervous system [CNS], such as encephalitis, meningitis, and meningoencephalitis are potentially life-threatening syndromes. They are caused by a diverse array of infectious causes. Despite being relatively uncommon, the morbidity, mortality, and costs are substantial. Of major importance are the herpes simplex virus [HSV]-2 and varicella zoster virus [VZV] in meningitis, and HSV-1 in encephalitis. Human herpes virus 6 [HHV-6] infection can induce severe encephalitis cases, particularly in immunocompromised. Human herpes viruses [HHVs] can cause CNS disease following primary infection, reactivation or recurrence