Clinical significance of lymphoid enhancer-binding factor 1 [LEF-1] expression in acute myeloid leukemia

ABSTRACT

Background: Lymphoid enhancer-binding factor-1 [LEF1] is a member of the LEF/T-cell factor family of transcription factors and a key mediator of the Wingless-type [Wnt] pathway. It mediates Wnt signals through recruiting beta-catenin and its co-activators to Wnt response elements of target genes. It plays crucial roles in normal hematopoiesis, not only in the development of B and T lymphocytes but also in granulopoiesis