Cardiac and hemodynamic changes with endotubation and suspension laryngoscopy and their prevention with intravenous lidocaine

ABSTRACT

Twenty patients were hospitalized for diagnostic or therapeutic procedures using suspension laryngoscopy. They were classified into two equal groups, nonpretreated lidocaine group [control group] that received general anesthesia only and pretreated lidocaine group that received intravenous lidocaine 2 mg/kg 2 minutes before induction of anesthesia. It was observed that there was an increase in mean arterial blood pressure, heart rate and rate pressure product at all observation times. This increase was significant immediately after intubation and with suspension. The increase in these parameters was more in the control group than in the lidocaine treated one. Also, transient ventricular extrasystole was recorded in 40% in the control group and 10% in the lidocaine pretreated group. A significant increase was found in paCo2 accompanied with a significant decrease in pH in both groups. These changes were more in the control group. There was also an increase in paO2 in both groups. This increase was more significant in lidocaine pretreated group