Treatment of PPI-resistant gastro-oesophageal reflux: a systematic review

ABSTRACT

Background and study aims: Several studies have demonstrated the superiority of proton-pump inhibitors [PPIs] in resolving erosive gastro-oesophageal reflux disease [GORD]. However, this first line of treatment can fail to control symptoms in around 30% of cases, especially in the presence of non-erosive GORD. In situations where the first line of treatment fails, there is a lack of concordance regarding the best strategy to apply. This study presents a systematic review of the trials which have tested second-line treatments after PPI failure