Effect of baicalein with different concentrations on myocardial ischemia reperfusion injury in rats

ABSTRACT

Baicalein is a kind of flavonoids. Long term use of flavonoids can reduce blood pressure by releasing physiological NO to keep the vascular endothelial function of hypertensive animals and reduce mysocardial ischemia injury. The purpose of this study is to explore the effect of baicalein on myocardial I/R damage and explore its mechanism of action, so as to provide experimental evidence for treatment. The results show that baicalein has a significant improvement in I/R damage, mainly in reducing myocardial infarction rate, reducing the release of myocardial isozyme LDH and CK, reducing the level of oxidative stress and reducing the apoptosis of cardiac myocytes. In the baicalein group, the myocardial ischemia state of isolated rat hearts was improved. Among them, myocardial infarction rate in low and middle concentration group was significantly decreased [P<0.05 or P<0.01], and there was no significant change in high concentration group [P>0.05]. The apoptosis rate of cardiac myocytes in the isolated group of baicalein was significantly decreased [P<0.01]. The role of baicalein in the cardiovascular system needs further test and clinical research