Skin mast cell promotion in random skin flaps in rats using bone marrow mesenchymal stem cells and amniotic membrane

ABSTRACT

Background: Skin flap procedures are employed in plastic surgery, but failure can lead to necrosis of the flap. Studies have used bone marrow mesenchymal stem cells [BM-MSCs] to improve flap viability. BM-MSCs and acellular amniotic membrane [AAM] have been introduced as alternatives. The objective of this study was to evaluate the effect of BM-MSCs and AAM on mast cells of random skin flaps [RSF] in rats