Association between hOGG1 polymorphisms and pancreatic cancer susceptibility: a Meta-analysis

ABSTRACT

Human 8-oxoguanine DNA glycosylase [hOGG1] plays a pivotal role in the initiating and progression of pancreatic cancer.Many studies implicated the association of hOGG1 polymorphism and pancreatic cancer susceptibility. However, the results remained inconclusive. The purpose of this meta-analysis was to investigate the relationship between hOGG1 polymorphism and pancreatic cancer susceptibility. Retrieved studies from Pubmed, Embase, Web of Science, Cochrane Library, and CBM databases about hOGG1 polymorphism and pancreatic cancer susceptibility were included in the final analysis with definite selection. Odds ratio [OR], 95% confidence interval [CI] and publication bias were calculated. Five related studies on hOGG1 polymorphisms [S326C, T2657C and R229Q] and pancreatic cancer susceptibility were included with 1,897 cases and 4,320 controls. The pooled results showed that hOGG1 polymorphisms S326C, T2657C, and R229Q were not associated with pancreatic cancer risk without publication bias. The current meta-analysis indicated that hOGG1 polymorphisms [S326C, T2657C and R229Q] are not associated with pancreatic cancer risk, but it needs further larger studies with ethnicity and various etiologies