Effect of chlorpromazine on the activity of cholinergic enzymes in the CNS of three mammalian species

ABSTRACT

The changes in ChAT and AChE activities were studied in discrete CNS regions of Gerbillus pyramidum, Cavia porcellus and Rousettus aegyptiacus following administration of chlorpromazine, [20 mg/100g body wt.]. Intraperitoneal injection with chlorpromazine provoked a general decrease in the two enzyme activities in all the CNS parts investigated. This decrease was marked in most of the regions after 1, 2 and 6 hours. The effect of chlorpromazine on AChE is variable from region to region which may be due to the difference in the content of glial or supportive tissue in the different CNS regions