Clinical research on therapeutic effect of combined application of lobaplatin and irinotecan in treating recurrant small cell lung cancer
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (5 Supp.): 2295-2298
in En
| IMEMR
| ID: emr-199866
Responsible library:
EMRO
To observe and analyze the therapeutic effect of combinated application of lobaplatin and irinotecan in treating recurrant small cell lung cancer. The 140 patients who were treated in our hospital for recurrant small cell lung cancer
were selected as research objects. All selected patients were subjected to combined application of obaplatin and irinotecan, the total therapeutic effect was observed, and the adverse reactions occurring during treatment were recorded.
Through observing the total treatment effective ratio of 140 patients recurrant small cell lung cancer, the number of complete remission cases, number of partial remission cases, number of stable disease cases, and number of disease
progression cases were 40[28.57%], 28[20.00%], 30[21.43%], 42[30.00%], respectively, with total effective ratio of 48.57%. The average time to progression [TTP] was [4.5±0.8] months, average overall survival [OS] was [7.6+/-1.2]
months. The toxic and adverse effects mainly included hematological toxicity and gastrointestinal adverse reaction, such as leukocyte reduction, neutrophil reduction, thrombocytopenia, decreased hemoglobin, nausea and vomiting, diarrhea. No toxicity-related death occurred. In treatment of patients with recurrant small cell lung cancer, the combined application of lobaplatin and irinotecan can achieve great results, which is a safe and reliable way of treatment
were selected as research objects. All selected patients were subjected to combined application of obaplatin and irinotecan, the total therapeutic effect was observed, and the adverse reactions occurring during treatment were recorded.
Through observing the total treatment effective ratio of 140 patients recurrant small cell lung cancer, the number of complete remission cases, number of partial remission cases, number of stable disease cases, and number of disease
progression cases were 40[28.57%], 28[20.00%], 30[21.43%], 42[30.00%], respectively, with total effective ratio of 48.57%. The average time to progression [TTP] was [4.5±0.8] months, average overall survival [OS] was [7.6+/-1.2]
months. The toxic and adverse effects mainly included hematological toxicity and gastrointestinal adverse reaction, such as leukocyte reduction, neutrophil reduction, thrombocytopenia, decreased hemoglobin, nausea and vomiting, diarrhea. No toxicity-related death occurred. In treatment of patients with recurrant small cell lung cancer, the combined application of lobaplatin and irinotecan can achieve great results, which is a safe and reliable way of treatment
Search on Google
Index:
IMEMR
Language:
En
Journal:
Pak. J. Pharm. Sci.
Year:
2018