Bone homeostasis in type II diabetes mellitus

ABSTRACT

This study was conducted on 80 cases of adult onset diabetes mellitus [type II DM]. There was significant increase in serum calcium, alkaline phosphatase, albumin, urea and creatinine. This was associated with high serum insulin level and low T3 levels which were measured by radioimmunoassay. The study showed that DM causes changes in mineral and calcium homeostasis but these changes were not related to serum glucose level, serum insulin level or the duration of DM. The decreased serum T3 and elevated serum reverse T3 [r T3] were found to progress towards normalization upon achievement of good metabolic control