Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain

ABSTRACT

Background: Various adjuvants have been used to prolong spinal anesthesia, with the additional advantages of delaying the onset of postoperative pain and reducing postoperative analgesic requirements. Pregabalin is an R-aminobutyric acid analog that binds to the á2-ä subunit of presynaptic voltage-gated calcium channels