Studies on the effect of dichlorvos and 2 PAM on rat brain acetylcholinesterase

ABSTRACT

Organophosphates are powerful, widely used pesticides which distrupt normal cholinergic neural impulse transmission of the central and peripheral nervous system in vertebrates by inhibiting AChE. Effect of three graded doses of Dichlorvos [3. 0, 1.5, 0.75 mg/kg b.w., i.p. daily for 7 days] was evaluated an acetylcholinerte-rase activity of rat brain and spinal cord. A dose response curve was obtained and it was observed that the spinal cord was the most susceptible region. Administration of pyridine - 2 - aldoxime, considerably reactivated the enzyme acetylcholinesterase. Variation in the reactivation of enzyme in the discrete regions of rat CNS suggests that individual regions behave as disparate organs and the extent of toxicity depends both on the region and the dose of Dichlorvos administered