Subacute and chronic toxicity of taxine in mice

ABSTRACT

The subacute and chronic toxicity of taxine, was investigated in mice. The drug was administered as sulphate salt at dosages of 4.5, 6, 8 mg/kg body weight by daily single subcutaneous injection. The treatment lasted 3 weeks for subacute and 3 months for chronic tests. The evaluated biochemical and hematological parameters as well as the pathological examinations and behavioural observations on the animals showed no harmful effect attributable to the drug. It was concluded that long-term application of taxine was well tolerated by mice