Comparison between the effect of the thiazolidinedione-rosiglitazone-and the sulphonylurea -gliclazide- and their combination on the liver of streptozotocin-induced diabetes mellitus in rats

ABSTRACT

This study was conducted to compare between the possible effects of rosiglitazone "A new oral antidiabetic drug with selective PPAR-gamma agonistic effect" in a dose of 0.03 mg/kg BW and gliclazide " An oral antidiabetic sulphonylurea" in a dose of 10 mg/kg BW either used alone or in combination, for 6 weeks on the liver, serum glucose and lipid profile in streptozotocin diabetic rats