Hyperhomocysteinemia modulates VEGF plasma levels and its expression in leucocytes in healthy subjects and in patients with peripheral arterial disease and diabetes mellitus

ABSTRACT

Aim: both homocysteine and vascular endothelial growth factor [VEGF] are implicated in development and progression of atherothrombotic vascular disease. We sought to determine whether there is a relationship between homocysteine and VEGF in healthy individuals and in patients with peripheral arterial disease [PAD] or diabetes mellitus [DM]