[ effect of reversible inactivation of locus coeruleus on long-term potentiation in the dentate gyrus of rat hippocampus]

ABSTRACT

Introduction: The nucleus locus coeruleus [LC] is located next to the fourth ventricle of the brain. Behavioral and electrophysiological studies have revealed the importance of LC noradrenergic projections in processes such as attention, learning and memory. Long-term potentiation [LTP] in hippocampal neurons is believed to be neural basis of learning and memory. The effects of LC on hippocampal electrophysiology have been investigated since many years ago, but have had different and conflicted results: