Correlation between hyperprolactinaemia and semen parameters

Background: A cross sectional study held in infertility clinics of Multan under supervision of Federal Postgraduate Medical Institute, Sheikh Zayed Hospital, Lahore. The aim of the study was to look for any correlation between serum prolactin levels and semen parameters in oligospermic or azoospermic infertile males. Where hyperprolactinaemia was the only hormonal abnormality

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Methods: We investigated 120 subjects [20 control and 100 infertile males]. The semen analysis was done according to WHO standard methods. The serum prolactin, FSH and testosterone were estimated by radioimmunoassay

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Results: Percent motility [p<0.001] and motile density [p<0.01] of sperms had a strong negative correlation with the serum prolactin levels. The sperm count and percentage of normal morphology were not correlated [p>0.05] to serum prolactin levels in such males

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Conclusion: Hyperprolactinaemia has a significant role in decreasing the sperm motility even without inducing hypo or hypergonadotropic hypogonadism