Leptin level and plasma prothrombotic factors in obese subjects

ABSTRACT

Obesity is associated with increased cardiovascular morbidity and mortality. Abnormalities in coagulation and haemostasis represent a well-known link between obesity and thrombosis [both arterial and venous]. In human, production of a depocyte-derived peptide, leptin has been linked to adiposity; recent studies have shown that plasminogen activator inhibitor-1 [PAI-1], a prothrombotic factor associated with atherosclerosis complication is also produced in adipose tissue. Several studies reported that obese subjects had elevated levels of vonWillbrand factor [vWF] and fibrinogen. The aim of this work is to examine the relationship of obesity, fat distribution and serum leptin concentration with plasma levels of Prothrombotic factors [PAI-1 - [vWF] and fibrinogen] and lipid pattern [Triglycerides and Cholesterol] as metabolic parameters. The body fat distribution was evaluated by measuring the body mass index [BMI] and waist-to-hip ratio [WHR]