Effect of some herbal medicine on some biochemical parameters in diabetic rats

The present study was carried out on eighty adult male albino rats [120 +/- 20gm b.wt]. They were randomly divided into eight groups. First group conserved as control group. The others groups received alloxan to become diabetic. The second group conserved as diabetic, the third group treated with a mixture of plants [0.5gm/120gm b.wt].From the fourth to eight group, the rats treated with Nigella sativa [0.25gm/120gm b.wt], Aloe vera, Ferulaassa-foetid, Boswellia Carterii Birdw and Commiphora myrrha respectively [0.5gm/120gm b.wt.]. Our result showed that the body weight was reduced significantly in diabetic group and Nigella sativa treated group. On the other hand, treatment with commiphora myrrha revealed significant increase in body weight gain, while mixture and Aloe vera treated rats recorded insignificant change. Diabetic rats revealed a significant decrease in serum glucose and DHEA-S levels and liver glycogen content, while insignificant difference was recorded in all treated groups. A significant decrease in serum insulin level was observed in diabetic group, Nigella sativa and Ferula assa-foetida treated groups, but insignificant different was recorded in the rest treated groups throughout the experiment. A significant increase in LDH activities in diabetic and Ferula assa-foetida treated groups was recorded while rest treated groups recorded insignificant change During experimental period