novel electrochemical DNA sensor via cyclic voltammetry and chronocoulometry for detection of single nucleotide polymorphism SNP A+49G of CTLA-4 gene associated with type one diabetes in Egyptian diabetic patients

ABSTRACT

Objective: To develop a novel electrochemical DNA biosensor and cost effective methodology for single nucleotide polymorphism [SNP] identification of autoimmune diseases generally and type one diabetes [IDDM] specifically compared to the conventional methods such as SSCP, TGGE and RFLP