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[Spontaneously acquired haemophilia A: a case report with bullous dermatosis and literature review]
JBM-Journal de Biologie Medical. 2018; 7 (26): 141-146
in French | IMEMR | ID: emr-202455
ABSTRACT
Acquired haemophilia is a rare disease; it occurs most frequently in elderly patients. We report the case of a 26 -year-old women, Thyroidectomized 5 years ago, Followed since 2013 for bullous dermatosis [bullous pemphigoid] currently under Corticotherapy, Under neuroleptic for a psychosis. Which presents a superficial hematoma of the left leg with spontaneous bruising. The diagnosis was established by the demonstration of an isolated prolongation of the activated partial thromboplastin time [APTT] with a reduced factor VIII level and evidence of factor VIII inhibitor activity to 92.1 Bethesda Unit [92,1 UB/ml]. Diagnosis of acquired haemophilia A confirmed, patient received corticosteroid treatment. Bleeding symptoms had completely disappeared and coagulation tests become normal. In conclusion, if bleeding symptoms are associated with unexplained prolongation of APTT, an inhibitor against factor must be searched for not missing an acquired coagulation disease
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Index: IMEMR (Eastern Mediterranean) Language: French Journal: J. Biol. Med. Year: 2018

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Index: IMEMR (Eastern Mediterranean) Language: French Journal: J. Biol. Med. Year: 2018