[Evaluation of phenytoin utilization based on key pharmacokinetic parameters in patients with head trauma]
Scientific and Research Journal of Army University of Medical Sciences-JAUMS. 2005; 3 (11): 619-623
in Persian
| IMEMR
| ID: emr-202481
ABSTRACT
Background:
Phenytoin is commonly administered as an anticonvulsant agent to critically traumatic patients for seizure prophylaxis and treatment. It exhibits non-linear pharmacokinetic characteristic and requires frequent plasma level monitoring and dose adjustment. Based on the previous study, it is often difficult to achieve therapeutic levels in patients with head trauma using the recommended phenytoin dosing strategies. Therefore, we conducted a prospective, randomized study to evaluate pharmacokinetic parameters of phenytoin in patients with head trauma
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Index:
IMEMR (Eastern Mediterranean)
Language:
Persian
Journal:
Sci. Res. J. Army Univ. Med. Sci.
Year:
2005
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