Nephrotoxic effects of griseofulvin on adult albino rats

ABSTRACT

Griseofulvin is a well known fungicide drug. It is used to treat dermatomycosis in many species. It has toxic effects on the liver, kidney, blood and chromosomes on prolonged use. This study was conducted to evaluate the nephrotoxic effects of chronic oral administration of griseofulvin on adult albino rats. The kidneys will be investigated histopathologically by light and electron microscopes and biochemically by measuring blood urea nitrogen and serum creatinine. This study was conducted on 30 normal adult albino rats of uniform strain. The rats were divided into three groups equally, The 1[st] group was used as a negative control group, the 2[nd] [positive control group] each rat was given 1 mL of olive oil orally once dally, the 3[rd] group each rat was given griseofulvin orally dissolved in 1 mL olive oil in a dose of 2500 mg/kg body weight [1120 of LD50] daily for 12 weeks. The affected glomeruli appeared shrinked with wide Bowman's spaces and adhesion of glomeruli to their Bowman's capsules. Most of the kidney tubules appeared distorted. The mean values of blood urea nitrogen and creatinine in griseofulvin treated group showed a statistically significant increase after 12 weeks when compared with positive control group. It can be concluded that griseofulvin is nephrotoxic on chronic administration to adult albino rats