Expression of T helper 17 cells retinoid acid related orphan receptor gamma-t [ROR-gamma-t] mRNA in systemic lupus erythematosus

ABSTRACT

Background: Systemic lupus erythematosus [SLE] is a systemic autoimmune disease characterized by various immunological abnormalities, including dis-regulating activation B lymphocytes with subsequent productionof a large quantity of autoreactive-antibodies. It is also hypothesized that T helper-17 lymphocytes [TH-17] may have a role in this disease. The aim of the present work was to determine the role of TH-17cells expressing the retinoid acid related orphan receptor gamma t [ROR-gamma-t] mRNA in the pathogenesis of SLE disease