Anti-Mucin1 aptamer-conjugated chitosan nanoparticles for targeted co-delivery of docetaxel and IGF-1R siRNA to SKBR3 metastatic breast cancer cells

Reza, Jafari; Naime, Zolbanin; Jafar, Majidi; Fatemeh, Atyabi; Mehdi, Yousefi; Farhad, Jadidi Niaragh; Leili, Aghebati Maleki; Dariush, Shanehbandi; Mohammad Sadegh, Zangbar; Houshang, Rafatpanah.

IBJ-Iranian Biomedical Journal. 2019; 23 (1): 21-33

in English | IMEMR | ID: emr-202859

ABSTRACT

Background:

Targeted co-delivery of siRNA and a chemotherapeutic drug is an attractive approach to cancer drug design and treatment. This study was carried out to design an anti-Mucin1 aptamer [Apt]-conjugated chitosan nanoparticle [NP] for targeted co-delivery of insulin-like growth factor receptor 1 [IGF-1R] Silencer siRNA and docetaxel [DTX] to SKBR3 cells

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Iran. Biomed. J. Year: 2019

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Iran. Biomed. J. Year: 2019