Effect of ulinastatin combined with octreotide on serum endothelin, endotoxin levels and immune function in acute pancreatitis

ABSTRACT

The aim of this study was to determine clinical efficacy of ulinastatin combined with octreotide in treatment of acute pancreatitis, and its effect on serum endothelin, endotoxin level and immune function. It was an analytical observational study carried out from September 2016 to March 2018. A total of 108 patients with acute pancreatitis were randomly divided into observation group and control group, 54 cases in each group. Control group was additionally treated with octreotide. Observation group was treated with ulinastatin. Therapeutic effects of two groups were compared. The total effective rate in observation group was higher than that in control group [p=0.046]. After seven days of treatment, serum endothelin and endotoxin levels in observation group were lower than those in control group [both p<0.001]; IgA, IgM and IgG levels in observation group were higher than those in control group [p=0.031, 0.007, and 0.001, respectively]. Ulinastatin combined with octreotide can reduce level of endothelin and endotoxin and improve immune function