Interleukin-2 level in mice infected with toxoplasma gondii

ABSTRACT

This work described the altered Interleukin-2 levels [IL-2] in mice infected with a virulent strain of Toxoplasma gondii and some possible mechanisms responsible for the alteration. To investigate this point, the effect of Toxoplasma infection was assessed shortly one week and then one month after invasion. Interleukin-2 production by stimulated Con A was reduced one week after infection and markedly depressed one month after infection with respect to normal controls. Unstimulated spleen cells from infected mice produced more IL-2 in vitro than stimulated cells. So, it can be concluded that IL-2 is one of the causes of immune suppression of Toxoplasmosis