Clinico-haematologic association and prognostic relevance of NPM1 and FLT3-ITD mutations in acute myeloid leukaemia

ABSTRACT

Background and Objectives: Molecular genetic abnormalities have a significant role not only in diagnosis but also in determining the clinical course and prognosis. Nucleophosmin-1 [NPM-1] is associated with good prognosis while internal tandem duplication of the fms-like tyrosine kinase-3 gene [FLT3-ITD] confers a poor prognosis. Knowledge of the status of these mutations in AML patients not only guides treatment decisions but also helps in predicting response to frontline induction and consolidation chemotherapy as well as the risk of relapse and overall survival. Our objectives were to determine the prevalence, clinico-haematological features and immunophenotypic characteristics of AML patients with FLT3-ITD and NPM1 mutation and to evaluate the response to induction therapy [CR] and disease free survival [DFS] in this cohort of patients