Does plasma beta-endorphin has a role in the pathogenesis of psoriasis?

ABSTRACT

Background: there is a controversy about the role of beta-endorphin in the pathogenesis of psoriasis, some reports demonstrated elevated circulating beta-endorphin in psoriatic patients especially with actively spreading plaques while lesion-free patients showed reduction of this neuropeptide. On the other hand, the here is published data denoting that circulating beta endorphin has no primary importance in the manifestation of the psoriasis and that inflammation in psoriatic skin lesions is probably not mediated directly by circulating P-endorphin