CD30-positive anaplastic large cell lymphoma of the skin in association with mycosis fungoides: a case report

ABSTRACT

CD30+ anaplastic large cell lymphoma [ALCL] can develop secondary from mycosis fungoides [MF]; a phemenon known as transformation of MF and is associated with aggressive clinical behavior. However, the coexistence of MF and CD30+ALCL runs an indolent course. Further dissection of the relationship between MF and CD30+ALCL is needed. We report a case of a 73 years old Yemeni woman who presented with a four months history of an ulcerated skin lesion of the left arm. Biopsy of that lesion demonstrated light microscopic features and immunohistochemical markers of CD30+ ALCL. Further examination of the patient revealed multiple eczematous lesions of the lower extremities. Biopsy of one of those lesions revealed histology of patch stage mycosis fungoides. The cell morphology and clinical behavior are consistent with MF and CD30+ALCL coexistence