Conformational analysis of [Pd [diethylenetriamine] [guanosine]] [CIO[4]][2]

ABSTRACT

[Pd [diethylenetriamine] [guanosine]][ClO4] 2 is used for the treatment of tumour. Potential energy calculations are performed to establish structure activity relationship of [Pd [diethylenetriamine] [guanosine]] [ClO4] 2. These calculations indicate that. the drug has allowed conformation in the region of 0 degree to 60 degree, 1600 to 240 degree and at 360 degree. The region of 80 degree to 140 degree and 260 degree to 340-degree rotation is not allowed. The most feasible position for the drug to interact with receptor would be at minimum potential energy in the regions from 0 degree to 60 degree, 160 degree to 240 degree and at 360 degree