Tris [dimethylamino] phosphine in phosphoranes synthesis. Studies on the activity of some novel synthesized phosphoranes and their behaviour as antibacterial, antifungal and pharmaco-logically active agents

ABSTRACT

Hydrazidoyl halides la-e reacted with tris [dimethylamino] phosphine 3 to yield the dipolar azomethylenephosphorane derivatives 4a-e. Similarly, the other types of hydrazidoyl halides 5a,b and 7a,b, interacted with tris[dimethyl-amino]phosphine to give the corresponding products 6a,b and 8a,b respectively. The antibacterial and the antifungal activities of the newly synthesized products were studied. The bioactivity of the newly obtained phosphorans as pharmacologically active agents to brine shrimp lethality was also tested