Spectrophotometric determination of cinnarizine, famotidine and metoclopramide hydrochloride using 2, 6-dichiorophenol indophenol

ABSTRACT

A simple, rapid, sensitive and accurate method for the determination of cinnarizine, famotidine and metoclopramide hydrochloride in pure form and in pharmaceutical formulations is develoed. The method is based on the reaction between dichlorophenol indophenol [DCPIP]and the cited drugs to give bluish violet radical ions exhibiting maximum absorption at 650, 642and 654 nm for cinnarizine, famotidine and metoclopramide respectively Optimizatiation of the experimental conditions is described Beer's law is obeyed from 15 to 140,10 to 65 and 3 to 9 ug ml[-1] for cinnarizine famotidine and metoclopramide respectively with molar absorptivities 2.421 x10[3], 4.313x10[3] and 2.112x10[4] L.mol[-1].cm[-1] for cinnarizine, famotidine and metoclopramide respectively and Sad ell sensitivities 6.569x10[-3], 1.278x10[-3] and 6.646x10[-3] ug cm[2-]. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the crresponding pharmaceuticals without any interferencs from common excipients