[ value of determining antipaternal leukocyte antibodies in the diagnosis of alloimmune factors in recurrent abortion]

ABSTRACT

Background: Habitual abortion is defined as the occurrence of three or more consecutive pregnancy losses before the twentieth week of gestation. This is a challengeable clinical issue, as no cause can be found for abortion in over 50% of patients. There is increasing evidence to support an alloimmune mechanism in the unexplained group. It has been stated that the absence of maternal antibodies against the paternal leukocyte antigen [APLA] presented by the fetus causes abortion in this group. The objective of this study was to determine the value of APLA in the diagnosis of immunological causes of unexplained habitual abortion