Diastolic dysfunction in patients with insulin dependent diabetes mellitus: as an early indicator of diabetic cardiomyopathy

ABSTRACT

Background: Diastolic abnormalities present in diabetic patients without diabetic complications or cardiovascular disease has been suggested as an earliest functional effect of a specific diabetic cardiomyopathy. Various abnormalities in diastolic function, e.g. prolonged isovolumic relaxation period, delayed mitral valve opening impairment in rapid diastolic filling, increased atrial contribution of LV filling, and reduced E/A mitral ratio have been characteristic findings: