Stress-induced factors colinked to chronic hepatic insult inducing fatigue influence of combined therapy

ABSTRACT

Objectives: The study aimed to evaluate the benefits of combined therapeutic strategy of multidisciplinary mechanisms in management of cases subjected to chronic hepatic insult inducing fatigue. They were co-linked to perturbations of immune, metabolic and hepatotoxic environmental stress-induced factors posed by cigarette smoking in subjects with Schistosomal hepatic fibrosis infected with hepatitis E [HEV] and/or of chronic hepatitis B [HBV] co-infection. Study Design Selected cases involved fifty cigarette smoker subjects with schistosomal hepatic fibrosis suffering from fatigue symptoms they included twenty five cases with HEV who were categorized into those with history of chronic HBV [Gr. Ia] or without [Gr. IIa] and 25 allied subjects without HEV with of either chronic HBV [Gr, IIIa] or recurrent schisosomal infection [Gr. IVa]. Control group [Gr. V] composed of 10 healthy nonsmokers were also included. The provided therapeutic regimen for 6 months had included ginko bilopa, ginsing, royal jelly, echinacea extracts and sylimarin. The subjects prior to therapy involved [Gr. Ia - Gr. IVa] and post therapeutically [Gr. Ib - Gr. IVb]