[Four cases of intraepithelial neoplasia of vulva: case report]

Background and Objective: VIN [Vulval Intraepithelial Neoplasia] is a rare disease that can be observed in young females. In this study, four VIN cases referred to the gynecologic oncology clinic of Ghaem and Omid hospitals [Mashhad] during a year are going to be introduced

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Cases: Four patients [Mean age 30 years] suffering from mass and itching vulva referred to our center. All had multifocal lesions. Risk factors such as HIV, STD and smoking showed negative results. Despite not having the possibility of examining HPV infection, two patients had koilocytosis pattern in pathologic examination. No patients had CIN and other related genital cancers. Surgery treatment in the form of local excision during the usage of acetic acid was performed in the operating ward. In two patients, the removed marginal tissue showed positive malignancy results had gone through orthovoltage radiotherapy. The recurrence was observed in one patient after one year who was reoperated in the form of skinning vulvectomy

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Conclusion: According to this fact that the major cause of VIN is STD and in more than 80% of patients is HPV infection the decrease in incidence of STD can especially lead to VIN decrease and vulva cancer naturally