IJRM-International Journal of Reproductive Biomedicine. 2018; 16 (8): 491-496
in English
| IMEMR
| ID: emr-204992
ABSTRACT
Background:
tumor protein p53 [TP53] is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 [MDM2], which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell apoptosis, polymorphisms that cause a change in their function might affect germ cell apoptosis and the risk of male infertility
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Int. J. Reprod. Biomed.
Year:
2018
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