In vitro hypoglycemic potential of spices: Cinnamon and Cumi

ABSTRACT

Present study evaluates the anti-hyperglycemic potential of two Indian spices Cinnamomum zeylanicum [CZ] and Cumin cyminum [CC] [whole powder and aqueous extracts] using in vitro techniques like glucose adsorption assay, amylolysis kinetics and ex vivo assays like amylase, Sucrase and ?-glucosidase assay. CZ displayed higher glucose adsorption and glucose diffusion retardation than CC, as shown by glucose adsorption and amylolysis kinetics assay. CZ showed lower inhibition of alpha-amylase and sucrase where as CC has no effect on both the enzymes. In case of alpha glucosidase, CC had better inhibition than CZ. Further research is needed to understand the mechanism through which both the spices act to regulate the hyperglycemia