Analysis of the advantages and disadvantages in application of oxygendriven aerosol and aerosol inhalation by air compressor for the pediatric asthma
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (6 Special): 2847-2850
in English
| IMEMR
| ID: emr-205122
ABSTRACT
Present study is done to analyze the advantages and disadvantages in application of oxygen-driven aerosol and aerosol inhalation by air compressor for the pediatric asthma. A total of 180 patients with pediatric bronchial asthma were randomized into the oxygen-driven aerosol group [Group A, n=90] and the air compressor-driven aerosol group [Group B, n=90]. Patients in both groups received 0.5 mg budesonide suspension, 0.2 mg salbutamol and 4 mL normal saline, and following the treatment, we recorded the excellence rate, improvement rate, total effectiveness rate, and the changes in oxyhemoglobin saturation [SaO2] before and after treatment, and the remission time in two groups. In Group A, patients had a higher total effectiveness rate [95.79% vs. 75.79%] but a lower failure rate [4.21% vs. 24.21%] than those in the Group B, with statistically significant differences [p>0.05]. Following the aerosol inhalation, SaO2 levels in two groups were ameliorated in comparison with the levels before treatment [Group A [95.4 +/- 0.4] % vs. [80.6 +/- 0.8%, Group B [92.1 +/- 1.1]% vs. [79.3 +/- 0.7]%] [p<0.05], and the level in Group A following the treatment was higher than that in Group B [[95.4 +/- 0.4] % vs. [92.1 +/- 1.1]%] [p<0.05]. Furthermore, patients in Group A had a longer effective remission time and total remission time than those in Group B, but the differences had no statistical significance [p>0.05]. Both of the oxygen-driven aerosol inhalation and aerosol inhalation by air compressor can improve the clinical symptoms of pediatric asthma effectively, but oxygen-driven aerosol inhalation works more efficiently, with an elevated SaO2. Thus, oxygen-driven aerosol inhalation is preferred in clinical practice
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2018
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